Effect of celecoxib on intra-abdominal sepsis-induced lung injury in rats

Objectives: This experimental study investigated the preventive effects of Celecoxib, a selective COX-2 inhibitor, on lung injury induced by intra-abdominal sepsis in rats. The assessed Celecoxib's potential to mitigate harmful impacts tissue. Methods: Thirty male Wistar albino rats, divided into three groups: normal control group, sepsis-induced group treated with saline, and Celecoxib. Sepsis was using fecal intraperitoneal injection (FIP), followed one-hour administration Celecoxib at 50 mg/kg/day treatment group. Biochemical analysis tissue measured oxidative stress markers (malondialdehyde [MDA]) pro-inflammatory cytokines (Tumor Necrosis Faftor-α [TNF-α]). Histopathological examination evaluated damage, encompassing alveolar congestion, hemorrhage, inflammatory cell aggregation, edema. Arterial blood gas quantified partial oxygen (PaO2) carbon dioxide (PaCO2) pressures. Results: Celecoxib-treated rats exhibited reduced lower MDA levels, indicating decreased damage Moreover, TNF-α other were significantly tissues its anti-inflammatory effects. revealed including aggregation. showed improved oxygenation compared untreated Conclusions: demonstrated against mitigating inflammation, thereby preserving integrity—further research, clinical trials, validate effectiveness safety human management.